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This Cajun Chicken Pasta is a creamy, spicy, and flavor-packed dish that’s perfect for weeknight dinners or special occasions. Tender chicken, bold Cajun spices, and a rich, cheesy sauce come together with perfectly cooked pasta for a satisfying meal. With simple ingredients and easy preparation, this homemade version rivals any restaurant dish. Whether you’re looking for a quick dinner idea or a meal to impress, this pasta delivers bold taste with every bite. Try it with different proteins, adjust the spice level, and make it your own!

Ingredients

Chicken

1 large boneless, skinless chicken breast
1 teaspoon Cajun seasoning
2 tablespoons flour
1-2 tablespoons olive oil

Pasta & Sauce

½ cup dry white wine (see notes)
3 tablespoons butter
3 cloves garlic, minced
2 tablespoons flour
1 tablespoon tomato paste
1 ¼ cups half and half (half cream, half milk)
¾ cup chicken broth
2 teaspoons hot sauce
1 teaspoon honey
10 oz. Rotel tomatoes with green chilies, drained
½ cup mozzarella cheese, shredded (see notes for alternatives)
½ cup cheddar cheese, shredded
½ lb. penne pasta

Seasonings

1 ½ teaspoons Cajun seasoning
1 teaspoon brown sugar
½ teaspoon EACH: onion powder, dried basil, oregano, mustard powder
1 pinch EACH: red pepper flakes, cayenne pepper

For Serving

Fresh cilantro

Instructions

Prep Work

In a medium measuring cup, combine the half and half, chicken broth, honey, hot sauce, and all seasonings. Set aside.
Before draining the pasta later, place a measuring cup in the colander as a reminder to save some pasta water.

Cook the Chicken

Slice the chicken in half lengthwise to create 2-3 thinner pieces. Pat dry and season both sides with Cajun seasoning. Sprinkle flour over each side and rub it in.
Heat olive oil in a large skillet over medium-high heat. Sear the chicken for 4-5 minutes per side until a golden crust forms. Remove from heat and let rest for 10 minutes before slicing into strips.
Meanwhile, start heating a pot of salted water for the pasta.

Prepare the Sauce

In the same skillet used for the chicken, add the wine over medium heat and let it reduce by half (about 3 minutes). Use a spatula to scrape up any browned bits from the pan.
Add butter and garlic, cooking for 1 more minute. Stir in the flour and cook for another 1-2 minutes. Mix in the tomato paste until well combined.
Gradually pour in the half and half mixture, stirring continuously. Bring to a gentle boil, then lower the heat to a simmer. Add the drained tomatoes and let the sauce cook while preparing the pasta.

Combine Everything

Cook the pasta to al dente according to package instructions. Drain, reserving 1 cup of pasta water.
Reduce heat to low and slowly sprinkle in the cheeses, stirring continuously until melted.
Stir in the drained pasta and sliced chicken, allowing it to heat through for 2 minutes.
If needed, add reserved pasta water for a creamier consistency.
Garnish with freshly chopped cilantro and serve immediately.

Why You’ll Love This Recipe

Bold & Spicy Flavors – Cajun seasoning and a creamy sauce create the perfect balance.
Restaurant-Quality Meal – Easy to make at home without sacrificing taste.
Quick & Easy – Ready in under 45 minutes with simple ingredients.
Customizable – Adjust spice levels and swap out ingredients to fit your preference.

Tips

Use Freshly Grated Cheese: Pre-shredded cheese contains additives that prevent it from melting smoothly.
Reserve Pasta Water: This helps thicken the sauce and allows the pasta to absorb more flavor.
Deglaze the Pan Properly: Scraping up the bits left from cooking the chicken adds extra depth to the sauce.
Adjust Spice Levels: Reduce or increase the Cajun seasoning, cayenne, and hot sauce to suit your taste.

Variations and Substitutions

Different Proteins: Swap chicken for shrimp, sausage, or tofu.
Vegetarian Option: Replace chicken broth with vegetable broth and use plant-based cream.
Cheese Substitutes: Gouda, Monterey Jack, or Parmesan work well.
Low-Carb Option: Use zucchini noodles or spaghetti squash instead of pasta.

FAQs

Can I make this ahead of time?

Yes! Store leftovers in an airtight container for up to 3 days. Reheat gently with a splash of milk or broth.

Can I freeze this dish?

The sauce may change texture after freezing. If freezing, store without the pasta and add freshly cooked pasta when reheating.

What if I don’t have white wine?

You can substitute with chicken broth or a splash of lemon juice for acidity.

Can I use a different pasta shape?

Absolutely! Try fettuccine, rigatoni, or bowtie pasta.

Serving Suggestions

Side Dishes: Serve with garlic bread, roasted vegetables, or a simple green salad.
Drink Pairings: Pairs well with a crisp white wine like Sauvignon Blanc or a light beer.
Extra Toppings: Sprinkle with extra cheese or crispy bacon bits for added texture.

This Cajun Chicken Pasta is rich, creamy, and packed with bold flavors, making it a go-to meal for any occasion!